関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | beta-Chloropivalic acid | HCID 83542 | — |
| 反応物 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-(1-Chloro-2-methylpropan-2-yl)-N-methyl-1,3,4-thiadiazol-2-amine | HCID 12769656 | — |
反応手順
An 87.2 g. portion of 4-methylthiosemicarbazide and 113.2 g. of 3-chloro-2,2-dimethylpropionic acid were suspended in 300 ml. of dioxane. The mixture was heated to 90° C. and 139.5 g. of phosphorus oxychloride was added dropwise while holding the temperature constant. After the addition was complete, the reaction mixture was stirred at 90° C. for three hours. The mixture was then allowed to cool and stand overnight at room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04028090 |
|---|
| 出典データセット | uspto-grants-1977_06 |
|---|
| ORD ID | ord-aee4a4e5815f4e63b86f62bb91b9377a |
|---|
| 出典メモ | uspto-grants-1977_06 |
|---|
