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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43676Generated: October 29, 2026

Methanol → HCID 86648619, compound

https://huagongshe.com/reaction/43676

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantHCID 86648618HCID 86648618—
SolventTetrahydrofuranHCID 8028—
ProductHCID 86648619HCID 8664861991%

Reaction Steps

The same operation as in Example (91d) was performed using butyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-5-propyl-3-methoxypiperidin-1-yl)-1,3-oxazole-4-carboxylate obtained in Example (116d) (0.22 g, 0.44 mmol), 2 N lithium hydroxide (3 mL, 6 mmol), methanol (2 mL) and THF (3 mL), to obtain 176 mg of the title compound as a colorless solid (91%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-bc7d2453e76c45e5bb709dc822e5d3bb
Source noteuspto-grants-2013_09