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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 436782Generated: October 25, 2026

1,3-Dibromo-2-propanone → 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine

https://huagongshe.com/reaction/436782

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Dibromo-2-propanoneHCID 69952—
Reactant7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepineHCID 12390887—
SolventTetrahydrofuranHCID 8028—
Product7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepineHCID 21431394—

Reaction Steps

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1,3-dibromopropanone under nitrogen to give 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04028356
Source datasetuspto-grants-1977_06
ORD IDord-463a7a8ab7a2457c9ee7e5fcdcdbd439
Source noteuspto-grants-1977_06