HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3-hydroxy-2-propanone → 7-chloro-2-[[2-chloro-1-(hydroxymethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3-hydroxy-2-propanone | HCID 90494 | — |
| Reactant | 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine | HCID 12390887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-chloro-2-[[2-chloro-1-(hydroxymethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine | HCID 86734822 | — |
Reaction Steps
In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-chloro-3-hydroxypropanone under nitrogen to give 7-chloro-2-[[2-chloro-1-(hydroxymethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04028356 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-02ce60070aa6422dabeac95ccfb3e408 |
| Source note | uspto-grants-1977_06 |