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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 436793Generated: October 25, 2026

1-Chloro-3-fluoro-propan-2-one → 7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

https://huagongshe.com/reaction/436793

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-3-fluoro-propan-2-oneHCID 228396—
Reactant7-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepineHCID 12390875—
SolventTetrahydrofuranHCID 8028—
Product7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepineHCID 54416851—

Reaction Steps

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-chloro-3-fluoropropanone under nitrogen to give 7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04028356
Source datasetuspto-grants-1977_06
ORD IDord-4c30f50382404e4a8ee6786b0e344893
Source noteuspto-grants-1977_06