Ammonium formate → tert-Butyl cis(+/-)-4-amino-3-isobutoxypiperidine-1-carboxylate

Participants

Reaction Steps

The same operation as in Example (90d) was performed using tert-butyl cis(±)-4-(benzylamino)-3-[(2-methyl-2-propen-1-yl)oxy]piperidine-1-carboxylate obtained in Example (117c) (1.8 g, 5 mmol), 10% Pd/C (wet, 0.5 g), ammonium formate (2.52 g, 40 mmol) and methanol (20 mL), to obtain 1.26 g of the title compound as a colorless oily substance (93%).

Provenance & Evidence