HCID 20322002, compound → HCID 20322001, compound

Participants

Reaction Steps

A mixture of 3.25g (1.6 × 10-2 mole) of 3-carbamoyl-2-dimethylaminopyrazolo[1,5-a]pyridine and 100 ml of concentrated hydrochloric acid was refluxed for 5 hours. After cooling, the solution was made to alkali and extracted with chloroform. The chloroform solution was dried over sodium sulfate and concentrated. The residue was column-chromatographed over alumina. The elution with methylene chloride gave crude product, which was recrystallized from n-hexane to give 1.3g of colorless needles, mp 51°-52° C. Yield 50%.

Provenance & Evidence