Acetyl chloride → HCID 12209691, compound

HRID 436808Notes

Reaction equation

HRID 436808 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][N:5]2[N:4]=1.[C:12](Cl)(=[O:14])[CH3:13]>>[C:12]([C:11]1[C:3]([O:2][CH3:1])=[N:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 122844272-Methoxypyrazolo[1,5-a]pyridine

Product 1

HCID 12209691HCID 12209691, compound

Procedure

A mixture of 2-methoxypyrazolo[1,5-a]pyridine (280 mg) acetic anhydride (3 ml) and acetyl chloride (1 ml) was refluxed for 1 hr and the reaction mixture was concentrated under reduced pressure. Water was added to the residue and the solution was made basic with potassium carbonate. The precipitated crystals were collected and washed with water. Recrystallization from n-hexane-ethyl acetate gave colorless needles, mp 158.0°-158.5°. Yield 160 mg.

Workup

  1. temperaturewas refluxed for 1 hr
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. additionWater was added to the residue
  4. customThe precipitated crystals were collected
  5. washwashed with water
  6. customRecrystallization from n-hexane-ethyl acetate
  7. customgave colorless needles, mp 158.0°-158.5°

Sources & evidence

ORD record
ord-3192493f208d4d8abac4238a3f511863
Source dataset
uspto-grants-1977_06
Patent number
US04028370

Reaction notes

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