反应详情

A mixture of 2-methoxypyrazolo[1,5-a]pyridine (280 mg) acetic anhydride (3 ml) and acetyl chloride (1 ml) was refluxed for 1 hr and the reaction mixture was concentrated under reduced pressure. Water was added to the residue and the solution was made basic with potassium carbonate. The precipitated crystals were collected and washed with water. Recrystallization from n-hexane-ethyl acetate gave colorless needles, mp 158.0°-158.5°. Yield 160 mg.

1. temperaturewas refluxed for 1 hr
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionWater was added to the residue
4. customThe precipitated crystals were collected
5. washwashed with water
6. customRecrystallization from n-hexane-ethyl acetate
7. customgave colorless needles, mp 158.0°-158.5°