Potassium Hydroxide → HCID 20321996, compound

HRID 436811Notes

Reaction equation

HRID 436811 reaction equation
[CH:1]([C:4]1[CH:12]=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2].[CH2:13]([O:15][CH2:16][CH:17]([CH3:21])[C:18](Cl)=[O:19])[CH3:14].[Cl-].[Al+3].[Cl-].[Cl-].[OH-].[K+]>C(=S)=S.O>[CH2:13]([O:15][CH2:16][CH:17]([CH3:21])[C:18]([C:12]1[C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][N:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=12)=[O:19])[CH3:14]

Participants

7

Reactant 4

HCID 14797Potassium HydroxideHCID 6451240Aluminum(III) ChlorideHCID 113786582-Isopropylpyrazolo[1,5-a]pyridineHCID 20321999HCID 20321999, compound

Product 1

HCID 20321996HCID 20321996, compoundYield 32%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6348Carbon DisulfideSolvent

Procedure

A mixture of 2-isopropylpyrazolo[1,5-a]pyridine and β-ethoxy-α-methylpropionic chloride was dissolved in carbon disulfide. Aluminum chloride was added at 0° to the resulting solution. The reaction mixture was stirred for 3 hr, and poured into water. The solution was made basic with potassium hydroxide solution and extracted with chloroform. The chloroform solution was washed with water, dried over sodium sulfate and concentrated. The residue was distilled, bp 171°-173° (4 mmHg). Yield 32%.

Workup

  1. extractionextracted with chloroform
  2. washThe chloroform solution was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. distillationThe residue was distilled

Sources & evidence

ORD record
ord-687b2fc29da744f78dcdb9c8cdbed997
Source dataset
uspto-grants-1977_06
Patent number
US04028370

Reaction notes

Loading…