反应详情

39.9 g (0.166 mole) of methyl 4-chlorosulfonylthiophene-3-carboxylate (VIII) is dissolved in 400 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After the mixture has been stirred for a further 3 hours (care being taken that the solution remains alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue can be recrystallized from ethanol; however, for further use, digestion with ether is sufficient.

1. customis passed in at room temperature until the mixture
2. customan alkaline reaction
3. extractionis extracted with water
4. customthe organic phase is dried
5. customevaporated
6. customThe crystalline residue can be recrystallized from ethanol