反应详情

43.5 g (0.181 mole) of methyl 3-chlorosulfonylthiophene-2-carboxylate (VIII) is dissolved in 450 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After stirring the solution for a further 3 hours at room temperature (care being taken to keep the solution alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue may be recrystallized from ethanol; however, for further reaction digestion with ether is sufficient.

1. customis passed in at room temperature until the mixture
2. customan alkaline reaction
3. extractionis extracted with water
4. customthe organic phase is dried
5. customevaporated
6. customThe crystalline residue may be recrystallized from ethanol