4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 1-nitro-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene

Participants

Reaction Steps

A solution of 2-[(5-methyl-4-imidazolyl)methylthio]ethylamine (8.56 g) in methanol (115 ml) was added dropwise over 13 minutes to a stirred solution of 1-methylsulphinyl-1-methylthio-2-nitroethylene (9.06 g) in methanol (150 ml) at 40°. Evaporation of the reaction mixture and recrystallisation of the resultant solid from isopropanol yielded the title product (7.15 g), m.p. 147°-150°.

Provenance & Evidence