反应详情

The product can be obtained in the form of a mixture of E and Z isomers by adding dropwise 3 ml of concentrated sulfuric acid to a solution of 7.6 g of the product of Example 3 in 45 ml of methanol and stirring the mixture at room temperature for 40 hours. The mixture was diluted with water and extracted with methylene chloride. The extracts were washed with water, dried over sodium sulfate and evaporated to dryness and the residue was chromatographed over silica and was eluted with a 9-1 benzene-ethyl acetate mixture to obtain 1.3 g of methyl 11-methoxy-7,11-dimethyl-3-oxo-6-dodecenoate in the form of a colorless oil.

1. customThe product can be obtained in the form of a mixture of E and Z isomers
2. extractionextracted with methylene chloride
3. washThe extracts were washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness
6. customthe residue was chromatographed over silica
7. washwas eluted with a 9-1 benzene-ethyl acetate mixture