HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Nalpha-[1(S)-ethoxycarbonyl-3-phenyl-3-oxo-propyl]-Nepsilon-t-butoxycarbonyl-(S)-lysyl-(S)-proline-t-butylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ethyl (2E)-4-oxo-4-phenyl-2-butenoate | HCID 5369605 | — |
| Reactant | H-Lys(Boc)-Pro-OtBu | HCID 14010669 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Nalpha-[1(S)-ethoxycarbonyl-3-phenyl-3-oxo-propyl]-Nepsilon-t-butoxycarbonyl-(S)-lysyl-(S)-proline-t-butylester | HCID 86741992 | — |
Reaction Steps
8.0 g (20 mmoles) of Nε -t-butoxycarbonyl-(S)-lysyl-(S)-proline-t-butylester are dissolved in 100 ml of diethyl ether and 4.48 g (22 mmoles) of E-ethyl-3-benzoyl-acrylate are added to the solution. The reaction mixture is stirred at room temperature for 5 hours. After evaporation of the solvent the title product is isolated on a Kieselgel column in the form of transparent oil. Rf =0.49 i(in a 7:3 eluent mixture of ethyl acetate and ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04725617 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-b8a5aa9b39d74e0b898f76e9233cf62f |
| Source note | uspto-grants-1988_02 |