HCID 86648633, compound → cis(+/-)-3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine

HRID 43691Notes

Reaction equation

HRID 43691 reaction equation
C([NH:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11][C@H:10]1[O:21][CH2:22][CH:23]([F:25])[F:24])C1C=CC=CC=1>[Pd].CO>[F:25][CH:23]([F:24])[CH2:22][O:21][C@H:10]1[C@@H:9]([NH2:8])[CH2:14][CH2:13][N:12]([C:15](=[O:20])[C:16]([F:19])([F:17])[F:18])[CH2:11]1

Participants

4

Reactant 1

HCID 86648633HCID 86648633, compound

Product 1

HCID 86648634cis(+/-)-3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amineYield 95.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The same operation as in Example (95b) was performed using cis(±)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine obtained in Example (121d) (1.1 g, 3 mmol), 10% Pd/C (wet, 0.35 g) and methanol (10 mL), to obtain 0.79 g of the title compound as a colorless oily substance (95%).

Sources & evidence

ORD record
ord-bf7265c9a12d42d58389160e768ca778
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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