反应详情

p-(Cyclobutylcarbonyl)phenylacetonitrile (8.1 g) in ethanol (50 ml) was added to potassium hydroxide (6.8 g) in water (50 ml) and the mixture was heated under reflux for 5 hours and cooled. The solution was diluted with water (100 ml), washed with ether (2× 100 ml), acidified to pH 1 with hydrochloric acid and extracted with ether (3× 100 ml). The combined extracts were dried over magnesium sulphate, filtered and evaporated to give a brown oil. This was extracted with a hot mixture of light petroleum (b.p. 60°-80°) and ethyl acetate (9:1) (3× 200 ml). The solid that crystallised from the extracts on cooling was collected. It had m.p. 91°-92.5°.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hours
3. temperaturecooled
4. washwashed with ether (2× 100 ml)
5. extractionextracted with ether (3× 100 ml)
6. dry with materialThe combined extracts were dried over magnesium sulphate
7. filtrationfiltered
8. customevaporated
9. customto give a brown oil
10. extractionThis was extracted with a hot mixture of light petroleum (b.p. 60°-80°) and ethyl acetate (9:1) (3× 200 ml)
11. customThe solid that crystallised from the extracts
12. temperatureon cooling
13. customwas collected