Ammonium Chloride → HCID 20309064, compound

Participants

Reaction Steps

3-(N-Benzyl,N-methylamino)-1,1-diphenyl-propan-2-one (10 g) in dry ether (250 ml.) was added to a solution of methyl magnesium iodide (from 2.4 g. magnesium and 14 2 g methyl iodide) in dry ether (250 ml.) and the mixture heated at reflux for 2 hours. Saturated ammonium chloride solution as added; isolation through ether in the usual manner gave 3-(N-benzyl,N-methylamino)-2-methyl-1,1-diphenyl-propan-2-ol, purified by chromatography on alumina using progressively graded mixtures of light petroleum and ether as eluant and isolated as the hydrochloride (6.8 g., 65%), m.p. 121° - 124° (from ethanol-ether).

Provenance & Evidence