2-Acetoxy-3-dimethylamino-1,1-diphenyl-propane → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 436944Notes

Reaction equation

HRID 436944 reaction equation
C([O:4][CH:5]([CH2:19][N:20]([CH3:22])[CH3:21])[CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)C>[OH-].[K+]>[CH3:22][N:20]([CH3:21])[CH2:19][CH:5]([OH:4])[CH:6]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 125491212-Acetoxy-3-dimethylamino-1,1-diphenyl-propane

Product 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-olYield 99%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

2-Acetoxy-3-dimethylamino-1,1-diphenyl-propane (200 mg) was dissolved in methanolic potassium hydroxide (5% 10 ml.) and the solution allowed to stand overnight. Solvent was evaporated and the residue dissolved in ether and water. The ether extract was dried and evaporated to give 3-dimethylamino-1,1-diphenyl-propan-2-ol (170 mg., 97%), m.p. 72° - 73°.

Workup

  1. customSolvent was evaporated
  2. dissolutionthe residue dissolved in ether
  3. extractionThe ether extract
  4. customwas dried
  5. customevaporated

Sources & evidence

ORD record
ord-d0c44a2c9e8a4dd7b1ea2d5809cfe90d
Source dataset
uspto-grants-1977_06
Patent number
US04028415

Reaction notes

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