HCID 12917795, compound → HCID 54362709, compound

HRID 436962Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]([C:18]([NH:20][C@H:21]([C:23]([NH:25][CH2:26][C:27](O)=[O:28])=[O:24])[CH3:22])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:30]([O:37][C:38](=[O:84])[C@H:39]([CH2:80][CH:81]([CH3:83])[CH3:82])[NH:40][C:41](=[O:79])[C@H:42]([CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)[NH:43]C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC1C=CC(O)=CC=1)NC(OC(C)(C)C)=O)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:30]([O:37][C:38](=[O:84])[C@H:39]([CH2:80][CH:81]([CH3:82])[CH3:83])[NH:40][C:41](=[O:79])[C@H:42]([CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)[NH:43][C:27](=[O:28])[CH2:26][NH:25][C:23](=[O:24])[C@H:21]([CH3:22])[NH:20][C:18](=[O:19])[C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)[NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

Reactant 2

HCID 12917795HCID 12917795, compound

HCID 54262973HCID 54262973, compound

Product 1

HCID 54362709HCID 54362709, compound

Procedure

When an equivalent quantity of N-t-butoxycarbonyl-L-tyrosyl-L-alanylglycine is substituted for the N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanine of Example 12 and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tyrosyl-L-alanylglycyl-L-phenylalanyl-L-leucine benzyl ester.

Sources & evidence

ORD record: ord-b86caae65fc04d79a85b2e4f5c7d74b2
Source dataset: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04028319

Reaction notes

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