HCID 11783563, compound → HCID 21431030, compound

HRID 436967Notes

Reaction equation

HRID 436967 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:18]([NH:20][CH2:21][C:22]([NH:24][CH:25]([C:27](O)=[O:28])[CH3:26])=[O:23])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:30]([O:37][C:38](=[O:56])[CH:39]([CH2:52][CH:53]([CH3:55])[CH3:54])[NH:40][C:41](=[O:51])[CH:42]([CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[NH2:43])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C(OC(N[C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)CC1C=CC(O)=CC=1)=O)(C)(C)C.C(OC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC=CC=1)N)C1C=CC=CC=1>>[CH2:30]([O:37][C:38](=[O:56])[CH:39]([CH2:52][CH:53]([CH3:54])[CH3:55])[NH:40][C:41](=[O:51])[CH:42]([CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[NH:43][C:27](=[O:28])[CH:25]([CH3:26])[NH:24][C:22](=[O:23])[CH2:21][NH:20][C:18](=[O:19])[CH:9]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[NH:8][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

5

Reactant 4

HCID 11783563HCID 11783563, compoundHCID 15916755HCID 15916755, compoundHCID 21431031HCID 21431031, compoundHCID 53837274HCID 53837274, compound

Product 1

HCID 21431030HCID 21431030, compound

Procedure

When equivalent quantities of N-t-butoxycarbonyl-DL-tyrosylglycyl-DL-alanine and DL-phenylalanyl-DL-leucine benzyl ester are substituted for the N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanine and L-phenylalanyl-L-leucine benzyl ester, respectively in Example 12 and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-DL-tyrosylglycyl-DL-alanyl-DL-phenylalanyl-DL-leucine benzyl ester.

Sources & evidence

ORD record
ord-fd82feb071be41dfb5b8b3125dda15d0
Source dataset
uspto-grants-1977_06
Patent number
US04028319

Reaction notes

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