HCID 54262973, compound → HCID 131710814, compound

HRID 436969Notes

Reaction equation

HRID 436969 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:18]([NH:20][CH2:21]C(CC(N)(C)C(O)=O)=O)=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:31]([O:35][C:36]([NH:38][C@H:39]([C:48]([N:50]([C:56](=[O:60])[CH:57]([CH3:59])[CH3:58])[CH:51]([NH2:55])[C:52]([OH:54])=[O:53])=[O:49])[CH2:40][C:41]1[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=1)=[O:37])([CH3:34])([CH3:33])[CH3:32].[CH2:61]([O:68][C:69](=[O:115])[C@H:70]([CH2:111][CH:112]([CH3:114])[CH3:113])[NH:71][C:72](=[O:110])[C@H:73]([CH2:103][C:104]1[CH:109]=[CH:108][CH:107]=[CH:106][CH:105]=1)[NH:74]C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC1C=CC(O)=CC=1)NC(OC(C)(C)C)=O)[C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=1>>[CH2:61]([O:68][C:69](=[O:115])[C@H:70]([CH2:111][CH:112]([CH3:113])[CH3:114])[NH:71][C:52](=[O:53])[C@:51]([NH2:55])([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[N:50]([C:48](=[O:49])[CH2:21][NH:20][C:18](=[O:19])[C@H:9]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[C:56](=[O:60])[CH:57]([CH3:58])[CH3:59])[C:62]1[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=1.[CH2:61]([O:68][C:69](=[O:115])[C@H:70]([CH2:111][CH:112]([CH3:113])[CH3:114])[NH:71][C:72](=[O:110])[C@H:73]([CH2:103][C:104]1[CH:109]=[CH:108][CH:107]=[CH:106][CH:105]=1)[NH:74][C:52](=[O:54])[CH:51]([NH2:55])[N:50]([C:48](=[O:49])[C@H:39]([CH2:40][C:41]1[CH:42]=[CH:43][C:44]([OH:47])=[CH:45][CH:46]=1)[NH:38][C:36]([O:35][C:31]([CH3:34])([CH3:32])[CH3:33])=[O:37])[C:56](=[O:60])[CH:57]([CH3:58])[CH3:59])[C:62]1[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=1

Participants

5

Reactant 3

HCID 54262973HCID 54262973, compoundHCID 86734849HCID 86734849, compoundHCID 131710816HCID 131710816, compound

Product 2

HCID 131710814HCID 131710814, compoundHCID 131710815HCID 131710815, compound

Procedure

When an equivalent quantity of N-t-butoxycarbonyl-L-tyrosylglycyl-α-aminoisobutyric acid or N-t-butoxycarbonyl-L-tyrosyl-α-aminoisobutyrylglycine is substituted for the N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanine of Example 12, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tyrosylglycyl-α-aminoisobutyryl-L-phenylalanyl-L-leucine benzyl ester or N-t-butoxycarbonyl-L-tyrosyl--α-aminoisobutyrylglycyl-L-phenylalanyl-L-leucine benzyl ester, respectively.

Sources & evidence

ORD record
ord-c5b2d5d378be4b089cd8933c3cbd0042
Source dataset
uspto-grants-1977_06
Patent number
US04028319

Reaction notes

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