HCID 86734847, compound → HCID 86734845, compound

HRID 436970Notes

Reaction equation

HRID 436970 reaction equation
[CH2:1]([O:8][C:9](=[O:56])[C@H:10]([CH2:52]CSC)[NH:11][C:12](=[O:51])[C@:13]([NH2:50])([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[N:14]([C:20](=[O:42])[CH2:21][NH:22][C:23](=[O:41])[C@H:24]([CH2:33][C:34]1[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=1)[NH:25]C(OC(C)(C)C)=O)[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])[C:2]1[CH:7]=CC=C[CH:3]=1.[CH2:57]([O:64][C:65](=[O:112])[C@H:66](CCSC)[NH:67][C:68](=[O:107])[C@H:69]([CH2:100][C:101]1[CH:106]=[CH:105][CH:104]=[CH:103][CH:102]=1)[NH:70][C:71](=[O:99])[CH:72]([NH2:98])[N:73]([C:79](=[O:97])[C@H:80]([CH2:89][C:90]1[CH:95]=[CH:94][C:93]([OH:96])=[CH:92][CH:91]=1)[NH:81]C(OC(C)(C)C)=O)[C:74](=[O:78])[CH:75]([CH3:77])[CH3:76])[C:58]1C=CC=C[CH:59]=1>>[NH2:25][C@H:24]([C:23]([NH:22][CH2:21][C:20]([N:14]([C:15](=[O:19])[CH:16]([CH3:17])[CH3:18])[C@:13]([NH2:50])([C:12]([NH:11][C@H:10]([C:9]([OH:8])=[O:56])[CH2:52][CH:58]([CH3:59])[CH3:57])=[O:51])[CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)=[O:42])=[O:41])[CH2:33][C:34]1[CH:35]=[CH:36][C:37]([OH:40])=[CH:38][CH:39]=1.[NH2:81][C@H:80]([C:79]([N:73]([C:74](=[O:78])[CH:75]([CH3:76])[CH3:77])[CH:72]([NH2:98])[C:71]([NH:70][C@H:69]([C:68]([NH:67][C@H:66]([C:65]([OH:64])=[O:112])[CH2:1][CH:2]([CH3:7])[CH3:3])=[O:107])[CH2:100][C:101]1[CH:102]=[CH:103][CH:104]=[CH:105][CH:106]=1)=[O:99])=[O:97])[CH2:89][C:90]1[CH:95]=[CH:94][C:93]([OH:96])=[CH:92][CH:91]=1

Participants

4

Reactant 2

HCID 86734847HCID 86734847, compoundHCID 86734848HCID 86734848, compound

Product 2

HCID 86734845HCID 86734845, compoundHCID 86734846HCID 86734846, compound

Procedure

Repetition of the procedure detailed in Example 13 using an equivalent quantity of N-t-butoxycarbonyl-L-tyrosyl-glycyl-α-aminoisobutyryl-L-phenylalanyl-L-methionine benzyl ester or N-t-butoxycarbonyl-L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-methionine benzyl ester affords L-tyrosylglycyl-α-aminoisobutyryl-L-phenylalanyl-L-leucine or L-tyrosyl-α-aminoisobutyrylglycyl-L-phenylalanyl-L-leucine, respectively.

Sources & evidence

ORD record
ord-4dd1967cebff48bd9c6d3fc0a3af1f07
Source dataset
uspto-grants-1977_06
Patent number
US04028319

Reaction notes

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