HCID 53837274, compound → HCID 86734847, compound

HRID 436971Notes

Reaction equation

HRID 436971 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:18]([NH:20][CH2:21][C:22](CC(N)(C)C(O)=O)=[O:23])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:31]([O:38][C:39](=[O:57])[C@H:40]([CH2:53][CH2:54][S:55][CH3:56])[NH:41][C:42](=[O:52])[C@H:43]([CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)[NH2:44])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.C(OC([NH:65][C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)CC1C=CC(O)=CC=1)=O)(C)(C)C.N[C@H](C(O)=O)CC1C=CC=CC=1.[CH2:99]([O:106]C(=O)[C@H](CC(C)C)N)[C:100]1[CH:105]=CC=C[CH:101]=1>>[CH2:31]([O:38][C:39](=[O:57])[C@H:40]([CH2:53][CH2:54][S:55][CH3:56])[NH:41][C:42](=[O:52])[C@:43]([NH2:65])([CH2:45][C:46]1[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=1)[N:44]([C:22](=[O:23])[CH2:21][NH:20][C:18](=[O:19])[C@H:9]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[C:99](=[O:106])[CH:100]([CH3:105])[CH3:101])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

5

Reactant 4

HCID 53837274HCID 53837274, compoundHCID 54314459HCID 54314459, compoundHCID 70633931HCID 70633931, compoundHCID 86734849HCID 86734849, compound

Product 1

HCID 86734847HCID 86734847, compound

Procedure

When equivalent quantities of N-t-butoxycarbonyl-L-tyrosylglycyl-α-aminoisobutyric acid and L-phenylalanyl-L-methionine benzyl ester are substituted for the N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanine and L-phenylalanine-L-leucine benzyl ester, respectively, of Example 12, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tyrosylglycyl-α-aminoisobutyryl-L-phenyl-alanyl-L-methionine benzyl ester.

Sources & evidence

ORD record
ord-005f63a73eb446be93bf717fe8a00d76
Source dataset
uspto-grants-1977_06
Patent number
US04028319

Reaction notes

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