Water → N-(2-Hydroxyethylamino)-ethanesulfonic acid

Temperature

10 °C

N-(β-hydroxyethyl)-2-aminoethanesulfonic acid, ##STR7## was prepared as follows: 2250 parts water was saturated with sulfur dioxide at 10° C. in a three-necked, round-bottom flask which was fitted with an electrical stirrer, thermometer, dropping funnel, and a gas inlet tube, 261 parts 1-aziridine-ethanol dissolved in 750 parts water was added via the dropping funnel while sulfur dioxide was bubbled into the flask and the temperature maintained at 10° C. After the addition was completed, the contents of the flask were concentrated to 600 parts and added to 3000 parts ethanol (F-30). The resulting solid was washed with 2000 parts ethanol, filtered, and dried to give 340 parts of the desired product.

1. customwas fitted with an electrical stirrer
2. customwas bubbled into the flask
3. additionAfter the addition
4. concentrationthe contents of the flask were concentrated to 600 parts
5. additionadded to 3000 parts ethanol (F-30)
6. washThe resulting solid was washed with 2000 parts ethanol
7. filtrationfiltered
8. customdried

ORD record

ord-8b1dd2dab67b4f09bbdd705fdb1075a9

Source dataset

uspto-grants-1977_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04029638