(+)-Estrone 3-methyl ether → HCID 10087777, compound

Participants

Reaction Steps

The procedure described in Example 1 hereinbefore was repeated but an equal amount of 3-methoxy-13β-methyl-17β-acetoxygona-1,3,5(10)-triene was substituted for the 3-methoxy-13β-methylgona-1,3,5(10)-trien-17-one that was used in that example. After distilling off the dichloromethane from the electrolyzed solution at a subatmospheric pressure and crystallizing from the remaining solution, 2.0 grams of 3-methoxy-13β-methyl-17β-acetoxygona-1,3,5(10),9(11)-tetraene having a melting point of 110°-113° C., was obtained. After recrystallization of the compound from a mixture of dichloromethane and methanol it had a melting point of 114°-116° C. and a specific optical rotation of +95° at a temperature of 25° C. for the sodium D line.

Provenance & Evidence