Ethanol → 6,7-Dichloro-3,4-dihydro-4-methyl-2H-pyrazino(2,3-b)(1,4)oxazine

Participants

Reaction Steps

The crude product from the reaction of tetrachloropyrazine (10.8 g, 0.05 mol) and methylaminoethanol (3.7 g, 0.05 mol) in Example 1 above was dissolved in absolute ethanol and small pieces of sodium (1.2 g, 0.05 mol) were added. After stirring overnight the ethanol was evaporated and the solid residue was washed with water, filtered, and dried on a porous plate to a weight of 7 g. The solid was recrystallized from ethanol and isopropyl alcohol (IPA) to give 4 g (27% yield) of a white solid, m.p. 170°-2°.

Provenance & Evidence