HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 4-Benzoyl-3-hydroxyphenyl 2-(4-Methylphenyl)-5-benzoxazolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2,4-Dihydroxybenzophenone | HCID 8572 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(4-Methylphenyl)-1,3-benzoxazole-5-carbonyl chloride | HCID 20390927 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Benzoyl-3-hydroxyphenyl 2-(4-Methylphenyl)-5-benzoxazolecarboxylate | HCID 53899050 | — |
Reaction Steps
A solution containing 5.42 g. (0.02 mole) of 1c, 4.28 g. (0.02 mole) of 2,4-dihydroxybenzophenone, and 0.8 g. (0.02 mole) of sodium hydroxide in 50 ml. of chloroform and 15 ml. of water was refluxed for 3 hours. After cooling, the layers were separated and the organic layer was concentrated to given 5.27 g. (59%) of 1e as a white crystalline solid: UV (CH2Cl2) λmax 306 nm (31,000), ε325 =18,500.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04029670 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-1a5376739c094ad389820769c4d6982f |
| Source note | uspto-grants-1977_06 |