Ethanol → HCID 131710818, compound

HRID 437062Notes

Reaction equation

HRID 437062 reaction equation
[C:1]([C:3]1[C:4]([C:17]2[N:18]([CH3:25])[C:19]([N+:22]([O-:24])=[O:23])=[CH:20][N:21]=2)=[N:5][N:6]([CH3:16])[C:7]=1[NH:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])#[N:2].C(O)C>N.O>[NH4+:2].[C:1]([C:3]1[C:4]([C:17]2[N:18]([CH3:25])[C:19]([N+:22]([O-:24])=[O:23])=[CH:20][N:21]=2)=[N:5][N:6]([CH3:16])[C:7]=1[NH:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])#[N:2]

Participants

5

Reactant 2

HCID 702EthanolHCID 57421991HCID 57421991, compound

Product 1

HCID 131710818HCID 131710818, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaCatalystHCID 962WaterSolvent

Procedure

To a suspension of 0.5 g. of N-[4-cyano-1-methyl-3-(1-methyl-5-nitroimidazol-2-yl)pyrazol-5-yl]oxamic acid, ethyl ester, in 25 ml. of ethanol, there were added with stirring, six drops of 28 percent ammonia in water. The mixture was stirred overnight at ambient room temperature. The reaction mixture was filtered and the solid which was collected was stirred for a few minutes in acetone at ambient room temperature and the solvent filtered off and discarded. The solid which was obtained weighed about 0.3 g. and had a melting point of about 175°-179° C. The solid was identified by NMR spectrum and elemental analyses as N-[4-cyano-1-methyl-3-(1-methyl-5-nitroimidiazol-2-yl)pyrazol-5-yl]oxamic acid, ethyl ester, ammonium salt.

Workup

  1. additionTo a suspension of 0.5 g
  2. stirringThe mixture was stirred overnight at ambient room temperature
  3. filtrationThe reaction mixture was filtered
  4. customthe solid which was collected
  5. stirringwas stirred for a few minutes in acetone at ambient room temperature
  6. filtrationthe solvent filtered off
  7. customThe solid which was obtained

Sources & evidence

ORD record
ord-a4ad5e537a464339997e6dbf59a118be
Source dataset
uspto-grants-1977_06
Patent number
US04029671

Reaction notes

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