Ammonia → 8-Quinolinecarboxamide, 5,6,7,8-tetrahydro-2-phenyl-

Participants

Reaction Conditions

Reaction Steps

Methyl 2-phenyl-5,6,7,8-tetrahydroquinoline-8 -carboxylate (4 g.) was dissolved in methanol previously saturated with ammonia (90 ml.) and heated in a bomb at 100° C. for 4 days. Removal of the solvent in vacuo gave an oily solid which on recrystallisation from ethyl acetate gave the title compound as colourless needles (1.5 g.) mp 145° C. Found: C, 76.4; H, 6.5; N, 11.1% C16H16N2O requires: C, 76.2; H, 6.4; N, 11.1%.

Provenance & Evidence