1-Methylpiperazine → HCID 178480778, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.0 g of 3-amino-7-chloro-2H-1,2,4-benzothiadiazine 1,1-dioxide and 2.5 g of 1-methylpiperazine is heated at 185° C. in a sealed tube for 8 hours. After removal of the remaining 1-methylpiperazine by distillation under reduced pressure, the residual solid is recrystallized from a mixture of dimethylformamide and water to give 2.8 g of the desired product, m.p. above 300° C.

Provenance & Evidence