4-Methylmorpholine → HCID 54170884, compound

Participants

Reaction Steps

To a solution of 0.005 mole of carbobenzyloxyalanine in 100 ml of dry tetrahydrofuran which has been cooled to -20° to -30° is added 1 ml of N-methylmorpholine and then 1 ml of isobutyl-chloroformate. After stirring for 10 minutes there is added 0.005 mole of alanylprolyl-2-azaalanine ethyl ester trifluoroacetic acid salt, 60 ml of chloroform and 1 ml of N-methylmorpholine. The reaction mixture is stirred overnight at room temperature, concentrated in vacuo, the residue treated with ethylacetate and the insoluble material removed by filtration. The filtrate is concentrated in vacuo and the residue chromatographed on a silica gel. Elution with ethyl acetate gives carbobenzyloxyalanylalanylprolyl-2-azaalanine ethyl ester.

Provenance & Evidence