Dimethylformamide dimethyl acetal → HCID 12747028, compound

Participants

Reaction Conditions

Reaction Steps

A 6.0 g. portion of 6-amino-2,3-bis(4-propyl-1-piperazinyl)quinoxaline (prepared as in Example 5) is mixed with 3.42 ml. of dimethylformamide dimethylacetal in a reaction flask fitted with a reflux condenser. The mixture is refluxed in an oil bath at 64° C. for three hours. The condenser is removed and the distillate is allowed to boil off as the oil bath is permitted to cool overnight. The flask is stripped of solvent by water pump evacuation and the residue is dissolved in 50 ml. of acetonitrile; is treated with activated charcoal and filtered. The filtrate is cooled at -10° C. causing separation of an oil. The supernatant is decanted and the oil is air dried to yield a crystalline solid which is recrystallized from 20 ml. of hexane by cooling at -10° C. The precipitate is filtered and is air dried to give the product of the example as a yellow solid, m.p. 95.5°-98° C.

Provenance & Evidence