1-Methylpiperazine → 4-(4-Methylpiperazine-1-yl)-3-sulfamoylbenzoic acid-ethylester

Participants

Reaction Steps

141 Grams of 4-chloro-3-sulfamoylbenzoic acid-ethylester (0.5 mole) were stirred for 1 hour at 110° C. with 250 ml of N-methylpiperazine. The crystalline precipitate obtained after the reaction solution had been poured into 2.0 l of water suction-filtered, was washed with water, dried on the steam bath and recrystallized twice from a mixture of diisopropylether and acetic ester.

Provenance & Evidence