1-Methylpiperazine → HCID 53722557, compound

Participants

Reaction Steps

165 Grams of 4-chloro-3-sulfamoylbenzoic acid-amide (0.7 mole) were stirred with 0.3 l of N-methylpiperazine for 1 hour at 130° C. Subsequently the reaction mixture was diluted with 2 l of water, and the crystalline precipitate was suction-filtered. The crude product (150 g with a degradation point of 301° C.) was dissolved in 3 l of 0.5N HCl and, after the solution had been decolorized with activated charcoal, the said product was precipitated in a crystalline state, at pH 8, by means of 2N ammonia.

Provenance & Evidence