Methanol → HCID 21430498, compound

Participants

Reaction Steps

40 Grams of 3-dimethylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoylchloride-hydrochloride (0.1 mole) were heated for 2 hours under reflux in 1 l of methanol. Subsequently the methanol was distilled off and the residue was dissolved in 0.3 l of water. A small amount of undissolved amorphous material was removed by filtration and the pH value of the filtrate was adjusted to 8 by means of concentrated aqueous ammonia, whereupon the final product precipitated immediately in a crystalline state. After it had been washed with water, it was dried on the steam bath.

Provenance & Evidence