Ammonia → HCID 21430459, compound

Participants

Reaction Steps

40 Grams of 3-dimethylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoylchloride-hydrochloride (0.1 mole) were heated under reflux for 2 hours with 0.4 l of n-butanol. Subsequently the n-butanol was eliminated in vacuo, the residue was dissolved in 0.5 l of water, and the pH value of the filtered solution was adjusted to 8.5 by means of 2N ammonia. The crystalline precipitate was suction-filtered, washed with water, then dried in vacuo at 40° C. and finally dissolved and reprecipitated from a mixture of acetic ester and diisopropylether.

Provenance & Evidence