Phenyl chloroformate → HCID 21430402, compound

HRID 437192Notes

Reaction equation

HRID 437192 reaction equation
[C:1]([N:4]([CH2:14][CH:15]1[O:20][CH2:19][CH2:18][N:17](CC2C=CC=CC=2)[CH2:16]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][CH2:12][CH3:13])(=[O:3])[CH3:2].Cl.C(N(CC1OCCN(CC2C=CC=CC=2)C1)C1C=CC=CC=1CCC)(=O)C.[C:56]1([O:62][C:63](Cl)=[O:64])[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1>C1(C)C=CC=CC=1>[C:1]([N:4]([CH2:14][CH:15]1[O:20][CH2:19][CH2:18][N:17]([C:63]([O:62][C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)=[O:64])[CH2:16]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][CH2:12][CH3:13])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 15891Phenyl chloroformateHCID 21430431HCID 21430431, compoundHCID 21430432HCID 21430432, compound

Product 1

HCID 21430402HCID 21430402, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-(N-Acetyl-2-n-propylanilino)methyl-4benzylmorpholine (2.2 g.) (prepared by basification of the hydrochloride described above) is azeotroped in toluene (30 ml.) until a clear dry solution is obtained. The solution is cooled and phenylchloroformate (1.2 g.) is added and the mixture is heated under reflux for 18 hours when the toluene is removed under reduced pressure. Crude 2-(N-acetyl-2-n-propylanilino)methyl-4-phenoxycarbonylmorpholine is obtained as an orange coloured oil.

Workup

  1. customis azeotroped in toluene (30 ml.) until a clear dry solution
  2. customis obtained
  3. temperatureThe solution is cooled
  4. temperaturethe mixture is heated
  5. customis removed under reduced pressure

Sources & evidence

ORD record
ord-fcfdbd6243b0441587f1ae6ce17fd59b
Source dataset
uspto-grants-1977_06
Patent number
US04029786

Reaction notes

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