2-Aminomethyl-4-tert-butyl-6-iodophenol hydrochloride → 2-Aminomethyl-4-t-butyl-6-iodophenol

Participants

Reaction Steps

A freshly-prepared solution of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride (5 g., 15 millimole) in water (100 ml.) is stirred at room temperature and basicified to pH ca.8 by addition of 15N ammonium hydroxide (excess) providing a fine slurry which is stirred at room temperature for 10 minutes and filtered. The collected solid is washed with water and dried in vacuo at 80° C. over phosphorous pentoxide for 2 hours to provide 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol as a colorless solid (4.2 g.), m.p. 146°-146.5° C. (dec.).

Provenance & Evidence