HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-4-Piperidylbenzamide → 1-[1-(4-Acetamidophenoxy)-2-hydroxyprop-3-yl]-4-benzamidopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-4-Piperidylbenzamide | HCID 118120 | — |
| Reactant | N-(4-((oxiran-2-yl)methoxy)phenyl)acetamide | HCID 2798712 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[1-(4-Acetamidophenoxy)-2-hydroxyprop-3-yl]-4-benzamidopiperidine | HCID 21430557 | — |
Reaction Steps
A solution of 2,3-epoxy-1-(4-acetamidophenoxy)-propane (5.18 g. and 4 -benzamidopiperidine (6.13 g.) in isopropanol (250 ml.) was refluxed for 24 hours, cooled and a white crystalline solid was filtered off (8.90 g.). This was recrystallised from isopropanol to give 7.41 g. of the title compound as a quarter hydrate, m.p. 226°-8° C. (Found: C, 66.35; H, 7.1; N, 10.1. C23H29N3O4.1/4H2O requires C, 66.4; H, 7.15; N, 10.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04029801 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-428508a1a3024595982b7ab62011906c |
| Source note | uspto-grants-1977_06 |