Formaldehyde → HCID 21430602, compound

HRID 437224Notes

Reaction equation

HRID 437224 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH2:12]=O.[C:14]([NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH:6]=1)[CH2:12][N:26]1[CH2:27][CH2:28][CH:23]([NH:22][C:14](=[O:21])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:24][CH2:25]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 1983AcetaminophenHCID 118120N-4-Piperidylbenzamide

Product 1

HCID 21430602HCID 21430602, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Acetamidophenol (1.51 g.) and 39.4% aqueous formaldehyde (1.25 ml.) were dissolved in 50% aqueous ethanol, and 4-benzamidopiperidine (2.04 g.) was added. The resulting solution was heated under reflux for 30 minutes then left overnight at room temperature. The white solid was collected and purified by suspending in boiling ethanol and filtering to give the title compound (1.32 g.), m.p. 242° C. (Found: C, 68.15; H, 7.1; N, 11.3. C21H25N3O3 requires C, 68.6; H, 6.9; N, 11.4%).

Workup

  1. temperatureThe resulting solution was heated
  2. temperatureunder reflux for 30 minutes
  3. customThe white solid was collected
  4. custompurified
  5. filtrationfiltering

Sources & evidence

ORD record
ord-dacdee53647e45f991a94da79a3efdde
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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