反应详情

1-[2-(p-Nitrophenyl)ethyl]-4-benzamidopiperidine (3.0 g.) was hydrogenated in absolute alcohol (400 ml.) at 50 p.s.i. and 20° C. for 3 hours in the presence of 300 mg. of platinum oxide as catalyst. The catalyst was filtered off and the solution evaporated to give the crude product as a foam. Crystallisation from a mixture of benzene and n-hexane gave the title compound, m.p. 193°-195° C. (Found: C, 74.4; H, 7.9; N, 12.9. C20H25N3O requires C, 74.3; H, 7.8; N, 13.0%).

1. filtrationThe catalyst was filtered off
2. customthe solution evaporated
3. customto give the crude product as a foam
4. customCrystallisation
5. additionfrom a mixture of benzene and n-hexane