Acetic Anhydride → HCID 21413256, compound

HRID 437230Notes

Reaction equation

HRID 437230 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>N1C=CC=CC=1>[C:25]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21413265HCID 21413265, compound

Product 1

HCID 21413256HCID 21413256, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-[2-(p-Aminophenyl)ethyl]-4-benzamidopiperidine (2.3 g.) was refluxed for 2 hours with acetic anhydride (22 ml.) in anhydrous pyridine (100 ml.). The solution was refrigerated for 24 hours and a crystalline product was filtered off, which after washing with ether yielded the title compound, m.p. 270°-275° C. (dec.). Found: C, 72.6; N, 7.55; N, 11.6. C22H27N3O2 requires C, 72.3; H, 7.45; N, 11.5%).

Workup

  1. filtrationa crystalline product was filtered off
  2. washwhich after washing with ether

Sources & evidence

ORD record
ord-c1e42f1f89c542289e2166e5bdfb9ec9
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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