HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 437236Generated: October 29, 2026
Potassium Carbonate → 1-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine
https://huagongshe.com/reaction/437236
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-4-Piperidylbenzamide | HCID 118120 | — |
| Reactant | 4-(2-Bromoethyl)-1,2-dichlorobenzene | HCID 15149389 | — |
| Product | 1-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine | HCID 21413253 | 94.2% |
Reaction Steps
4-Benzamidopiperidine (204 mg.) and anhydrous potassium carbonate (138 mg.) were intimately ground together and added to 2-(3,4-dichlorophenyl)ethyl bromide (254 mg.). The resulting paste was heated at 100° C. for 2 hours to give a hard solid. This was broken up, washed well with water and ether and dried to give the title compound (355 mg.). Recrystallisation from ethanolic hydrogen chloride and ether gave the hydrochloride (237 mg.), m.p. 286.0° C. (Found: C, 58.2; H, 5.8; N, 6.8. C20H22Cl2N2O.HCl requires C, 58.05; H, 5.6; N, 6.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04029801 |
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| Source dataset | uspto-grants-1977_06 |
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| ORD ID | ord-a573edf98c094f8e8fcbc186544096e3 |
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| Source note | uspto-grants-1977_06 |
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