Hydrochloric Acid → HCID 21430568, compound

Participants

Reaction Steps

A solution of 6-chloroacetyl-1,2,3,4-tetrahydro napthalene (20.87 g.), 4-benzamidopiperidine (20.4 g.) and trimethylamine (11.1 g.) in dimethylformamide (200 ml.). was stirred for 3 days at room temperature. The crystals which had formed during this time were then filtered off, washed and dried. A portion of this crystalline solid (4.0 g.) was dissolved in ethanol (50 ml.) and acidified with ethanol hydrogen chloride to give 4.0 g. of the hydrochloride of the title compound, m.p. 270° C. (decomp.). (Found: C, 69.5; H, 7.2; N, 6.8; C24H28N2O2.HCl requires C, 69.8; H, 7.1; N, 6.8%).

Provenance & Evidence