Acetic Acid → HCID 21430597, compound

HRID 437256Notes

Reaction equation

HRID 437256 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)=[CH2:2].[C:9]([NH:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(O)(=O)C>CO>[N:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH2:2][N:21]2[CH2:22][CH2:23][CH:18]([NH:17][C:9](=[O:16])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:19][CH2:20]2)=[CH:4][CH:5]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 75024-VinylpyridineHCID 118120N-4-Piperidylbenzamide

Product 1

HCID 21430597HCID 21430597, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-vinylpyridine (578 mg.), 4-benzamidopiperidine (1.02 g.), acetic acid (330 mg.) and methanol (5 ml.) was refluxed for 8 hours, cooled, and evaporated. The residue in water was basified with potassium carbonate and the resulting solid was collected. Recrystallisation from aqueous ethanol gave the product (1.24 g.) m.p. 193°-5° C. (Found: C, 73.3; H, 7.4; N, 13.3. C19H23N3O requires C, 73.75; H, 7.4; N, 13.3%.).

Workup

  1. temperaturewas refluxed for 8 hours
  2. temperaturecooled
  3. customevaporated
  4. customthe resulting solid was collected
  5. customRecrystallisation from aqueous ethanol
  6. customgave the product (1.24 g.) m.p. 193°-5° C. (Found: C, 73.3; H, 7.4; N, 13.3. C19H23N3O requires C, 73.75; H, 7.4; N, 13.3%.)

Sources & evidence

ORD record
ord-7f1eb31d8c624960a4ae09fc213a1450
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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