p-Toluenesulfonic acid monohydrate → HCID 86734859, compound

Participants

Reaction Steps

To a stirred slurry of 4.72 g. (0.010 mole) 6-triphenylmethylamino-2,2-dimethyl-3-(O-methylphosphono)penam in 50 ml. of dry acetone was added 1.90 g. (0.010 mole) of p-toluenesulfonic acid monohydrate at ambient temperature. The solids dissolved slowly to afford a clear solution. After stirring for about 15 minutes the product started to precipitate. After stirring for about one hour the product was removed by filtration and washed with acetone. 1H-nmr (DMSO-d6) ppm (δ): 1.62 (s,3,CH3), 1.70 (s,3, CH3), 3.62 (d, J=11,3, OCH3), 3.88 (d, J=11,1,C-3), 5.05 (m,1,C-6), 5.37 (d, J=4,1, C-5). IR(Nujol mull): 1765 cm-1 (β-lactam).

Provenance & Evidence