Nitric Acid → HCID 54711107, compound

HRID 437361Notes

Reaction equation

HRID 437361 reaction equation
[OH:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]([CH3:12])[CH2:7][C:6]=2[NH:5][C:4](=[O:13])[CH:3]=1.[N+:14]([O-])([OH:16])=[O:15].O>C(O)(=O)C>[OH:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]([CH3:12])[CH2:7][C:6]=2[NH:5][C:4](=[O:13])[C:3]=1[N+:14]([O-:16])=[O:15]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 54711100HCID 54711100, compound

Product 1

HCID 54711107HCID 54711107, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 4-hydroxy-7-methyl-5,6,7,8-tetrahydrocarbostyril, (1.608 g; 0.009 mole) in glacial acetic acid (10 ml) was treated with concentrated nitric acid (2.5 ml; d 1.42) and the clear solution heated at 100° C until the exothermic reaction set in (ca 7 mins). After rapid cooling water (40 ml) was added and the yellow solid filtered off and recrystallised from ethanol; acetic acid, m.p. 238° (d).

Workup

  1. additionwas added
  2. filtrationthe yellow solid filtered off
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-c7b9d3ad0de44d51b0d97e5d7e7c57a4
Source dataset
uspto-grants-1977_06
Patent number
US04031099

Reaction notes

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