HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Pirbuterol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | α-[[(1,1-Dimethylethyl)amino]methyl]-2,2-dimethyl-4H-1,3-dioxino[5,4-b]pyridine-6-methanol | HCID 21428405 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Pirbuterol hydrochloride | HCID 68658 | — |
Reaction Steps
To 10 ml. of methanol and 10 ml. of 10% hydrochloric acid is added 227 mg. of 2,2-dimethyl-6-(1-hydroxy-2-t-butylaminoethyl)-4H-pyrido[3,2-d]-1,3-dioxin, and the resulting reaction mixture allowed to stir at room temperature for 1.5 hrs. Removal of the solvents under vacuum at 70° C. provides 230 mg. of the desired product, which is identical by nuclear magnetic resonance spectroscopy to the product in U.S. Pat. No. 3,700,681.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031108 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-698ce46ad0944fa2883190a1369c92ab |
| Source note | uspto-grants-1977_06 |