HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicarbonate Ion → Fluoromidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicarbonate Ion | HCID 769 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE | HCID 20359924 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Fluoromidine | HCID 911208 | 73% |
Reaction Steps
1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031107 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-fde4c1ece5ef45c68a2011d043d95a1d |
| Source note | uspto-grants-1977_06 |