Acetic Acid → HCID 12535821, compound

Participants

Reaction Steps

Diethyl ethoxymethylenemalonate (1.18 g., 5.45 mmoles) was added to a cold, stirred mixture of sodium ethoxide (0.37 g., 5.45 mmoles) and 5-carbomethoxy-2-ethoxybenzamidine (1.21 g., 5.45 mmoles) in ethanol (15 ml.). The mixture was heated under reflux for 0.5 hours. The cooled mixture was poured onto ice-water and acidified with acetic acid. The precipitate was recrystallized from ethanol to give the title compound (1.49 g., 76%) as colorless crystals, m.p. 180°-181.5°.

Provenance & Evidence